abstract |
An Epstein-Barr virus (EBV) -negative NK cell line was provided. The NK cell line of the present invention is useful for screening factors associated with NK cell growth and functional expression, or for searching for factors produced by NK cells. In addition, in this cell line, cells are immortalized despite being EBV negative. From this, elucidating the mechanism of immortalization of the cell line of the present invention may lead to elucidation of an unknown mechanism of canceration. |