| abstract |
Provided is a novel nitrogen-containing compound having CXCR4 antagonistic activity and a therapeutic agent for diseases such as rheumatism and cancer metastasis based on CXCR4 antagonistic activity. A nitrogen-containing compound represented by the following formula and a CXCR4 antagonist containing the compound as an active ingredient. Typically, in the following general formula (I), A 1 and A 2 are each represented by a guanidino group or the following formula (ia), and A 3 is a monocyclic or polycyclic heteroaromatic containing one or two hetero atoms. A ring group, B 1 is a single bond or an alkylene group, R 1 is hydrogen or an alkyl group, W is an alkylene group having 2 to 3 carbon atoms, a cyclic alkylene group having 5 to 10 carbon atoms, aromatic ring of 10, a heteroaromatic ring from 10 5 carbon atoms, y is -C (= O) -, x is represented by -C (= O) -NH-, n 1 is from 1 2 A compound wherein n 2 is an integer of 2 to 3 and D is various substituents. |