| abstract |
General formula (I) (Wherein, R 1 represents an alkyl group, an aryl group, or a heteroaryl group which may have a substituent, and R 2 and R 3 represent a hydrogen, a hydroxyl group, an alkyl group which may have a substituent, etc. R 4 represents hydrogen, an alkyl group which may have a substituent or the like; X represents hydrogen, a halogen atom, a hydroxyl group, an alkyl group which may have a substituent, an aryl group, a heteroaryl group, an amino group; And Y represents an oxygen atom or a sulfur atom.) A pharmaceutical composition comprising, as an active ingredient, a heterocyclic compound represented by the formula (I), an isomer thereof, a solvate or a pharmaceutically acceptable salt thereof has an excellent TNF-α production inhibitory action. Therefore, it is useful for prevention and treatment of various diseases caused by abnormal production of TNF-α. |