abstract |
Provided are compounds useful as PGI 2 receptor agonists, and pharmaceutical compositions. The present invention provides the following formula [1] (R 1 and R 2 are the same or different and each represents an optionally substituted aryl. Y represents N, CH or the like, Z represents N or CH or the like. A represents NH, NR 5 , O , S or ethylene, R 5 represents alkyl, etc. D represents alkylene or alkenylene, E represents phenylene or a single bond, G represents O, S or CH 2, etc. R 3 , R 4 are the same or different and represent hydrogen or alkyl, and Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, N- (alkylsulfonyl) carbamoyl, or the like. It is composed of a pharmaceutical composition containing an acceptable salt as an active ingredient. |