| abstract |
General formula (I) [Wherein, R 1 represents hydrogen or a lower alkyl group, A represents a morpholino group or a general formula (II) (Where B is a hydroxy lower alkyl group or a carbamoyl group, or a glycyl group optionally substituted with an amino group). And a pharmaceutical containing the compound represented by the formula: The compound of the present invention has potent cysteine protease, especially calpain inhibitory activity, and has appropriate water solubility desired as a pharmaceutical. |