| abstract |
A host capable of functioning as a nerve cell, created by introducing and expressing a von Hippel-Lindau gene in a cancer cell or embryonic stem cell such as a neuroblastoma cell, an undifferentiated tumor cell derived from the nervous system. The obtained host is proliferated in vitro, transplanted into the central nervous system or peripheral nerve, and allowed to engraft and function as a nerve cell, so that Parkinson's disease related to impaired nerve function, muscle atrophic side Treat intractable neurological diseases such as sclerosis, Huntington's disease, Alzheimer's disease, cerebral infarction, spinal cord injury, cerebral contusion or malignant tumor. |