| abstract |
The HK33 protein was found to bind to the ARF protein. Expression of the HK33 gene inhibited nuclear translocation of the ARF protein and suppressed p53-dependent transcription. Furthermore, in the immortalized cells, the expression of the HK33 gene was significantly increased. The present invention relates to a method for screening a drug having an antitumor effect utilizing an interaction between an ARF protein and a HK33 protein, a method for regulating signal transduction via the ARF protein by targeting the HK33 protein, a molecule used therefor, and a tumor, etc. It provides the use of the HK33 protein and the gene encoding the HK33 protein for testing in disease. According to the present invention, it is possible to screen for a new drug having an antitumor effect using the interaction of the HK33 protein with the ARF protein as an index. |