http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6479176-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44c713790ce00813da2e6c6d57a29456 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate | 1987-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e59fdd6e0c76967e87b2d6362e3a7463 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_757006083437dd25212ad5d4b229b1c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c08d4b486559c4cf8746cbb5843b2215 |
| publicationDate | 1989-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6479176-A |
| titleOfInvention | Intermediate of acromelic acid |
| abstract | NEW MATERIAL:A compound of formula I (R is H, lower alkyl; R<1> is benzyl, t-butoxycarbonyl; R<2> is 1-3C alkyl, R<3> is alpha-hydrogen atom, beta-hydrogen atom). USE:An intermediate of acromelic acid and its relating compounds which has nervous system depolarization action and anthelmintic action, and can give the acid from easily available chemicals through reduced steps. PREPARATION:The compound of formula 5 is prepared from a compound of formula II through 4 steps, and allowed to react with BBr3 into a compound of formula 6. The product is treated with sodium hydroxide to open the lactone ring, then oxidized with NaIO4, CrO3 into carboxylic acid, and the acid is esterified with methanol and sulfuric acid into the compound of formula 7 in formula I. The compound of formula 7 is allowed to react with NaH and 1,8-diazabicyclo[5.4.0]-7-undecene into the compound of formula 8 in formula I. The compound of formula 7 can be directly synthesized from the compound of formula 5, too. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5341195-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103237780-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012074012-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-5199519-B2 |
| priorityDate | 1987-02-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.