| abstract |
PURPOSE:To provide a medicinal drug having the form of fine particles with an average particle diameter falling within a specific range, composed of a benzoylurea compound, having excellent carcinostatic activity, high absorbability through digestive tracts and good particle stability in liquid state and administrable without pain and said action of the patient. CONSTITUTION:At least one kind of benzoylurea compound selected from the compound of formula I (X is halogen, nitro or trifluoromethyl; Y is H, halogen, nitro or trifluoromethyl; when Y is nitro, X is halogen or nitro; Z1 is halogen or trifluoromethyl; Z2 is H or halogen; A is =CH- or N) and the compound of formula II (X1 and X2 are H, halogen or nitro; Y is H, halogen, nitro or trifluoromethyl; when Y is nitro, X is H; Z is H, halogen or trifluoromethyl) is crushed in a solution added with a dispersing agent and is used in the form of fine particles having an average particle diameter of <=1mum, especially 0.3-0.8mum. |