| abstract |
PURPOSE: To obtain the subject preparation which contains urea, amino acids and nonionic moistening agent, maintains effective action in vivo and can be simply prepared to an injection form without sticking to the walls of ampoules or syringes. CONSTITUTION: This human protein preparation contains a human protein (for example, erythropoietin or t-PA), a physiologically tolerant buffer solution (20-100mmol/L concentration with a pH of 6.5-7.4, particularly 7.0-7.2), when necessary, a complex builder, an isotonic controller, calcium chloride and other common substances used in injection solutions. This human protein preparation is combined with 5-50g, particularly 10-15g of urea, 0.5-50g, particularly 1-20g of an amino acid (for example, glycine, L-alanine, L-arginine) and 0.05-5g, particularly 0.1-0.5g of a nonionic moistening agent (for example, polyoxyethylene sorbitan laurate), when it is used in the form of injection solution. |