http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6468333-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-743 |
| filingDate | 1987-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_500df22f31661f9aa117e582f506d50e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eee9dd7a2088328e9a63c3017d2d789a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc73a53703b5cdb6582ae13ea7614f2c |
| publicationDate | 1989-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6468333-A |
| titleOfInvention | Production of isocarbacyclin intermediate |
| abstract | PURPOSE:To efficiently obtain the titled intermediate useful as a medicine from readily available raw materials, by directly introducing an alkenyl chain corresponding to the aimed compound into beta-keto esters containing a bicyclo[3.3.0]octane skeleton and chemically converting the resultant product. CONSTITUTION:A compound expressed by formula I [R<1> is H or CH3; R<2> is 1-8C alkyl, substituted or unsubstituted benzyl or trichloroethyl) is reacted with an active species obtained by treating a compound expressed by formula II (R<3> is tri-1-7C hydrocarbon-silyl or group capable of forming acetal bond with O of OH; R<4> is H, CH3 or vinyl; R<5> is 3-8C alkyl which may contain O, phenyl, phenoxy, etc.; n is 0 or 1) with mercuric chloride or zinc chloride and then lead tetraacetate, as necessary, in the presence of a base to provide a compound expressed by formula III, which is subsequently subjected to reaction for removing the ester group to afford a compound expressed by formula IV. The carbonyl group thereof is then reduced and the resultant compound is simultaneously subjected to deprotection reaction to readily afford the aimed compound expressed by formula V and/or an optical isomer thereof from the above-mentioned raw materials in short steps. |
| priorityDate | 1987-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.