| abstract |
NEW MATERIAL:A compound expressed by formula I {R is H, formula II [lis 0 or 1; D is CHNR<5>R<6> (R<5> and R<6> are H, alkyl, alkanoyl, benzoyl, etc.) or NR<7> (R<7> is H, alkanoyl, alkylsulfonyl, etc.)] or formula III (R<3> is H or alkyl; R<4> is phenylalkyl, anilinoalkyl, etc.); R<1> is H, alkyl, phenyl, phenylalkyl, etc.; R<2> is H, alkyl or phenyl; A is CH2, CO etc.; B is CO, CS, etc.} and salt thereof. EXAMPLE:6-[4-(3,4-Dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2-quina zolone. USE:Useful as remedy for various kind of heart diseases because of having excellent positively inotropic action, coronary blood flow increasing action and depressing action and having no increasing action of heat beat numbers on the other hand. PREPARATION:For example, a compound expressed by formula IV is reacted with a compound expressed by formula V (B' is CO or CS; R'' is halogen, alkoxy, etc.; R<12> is halogen, imidazolyl, etc.) to provide the compound expressed by formula I. |