http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6452760-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 1987-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b6e0afeab3cabaccbffdf3c64fd16c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e0549c31824ad6c720999c3d5532f7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f84ec2cd306edf7bcd8abcd56b3c323 |
| publicationDate | 1989-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6452760-A |
| titleOfInvention | Production of imidazole derivative |
| abstract | PURPOSE:To obtain the titled compound useful as an intermediate for cimetidine at a low cost, by reacting 4-methyl-5-hydroxymethylimidazole with S,S'-bis(2- aminoethyl)dithiocarbonate as raw materials in acidic solvent. CONSTITUTION:Readily synthesized 4-methyl-5-hydroxymethylimidazole is reacted with S,S'-bis(2-aminoethyl)dithiocarbonate expressed by formula II which can be readily synthesized by reacting 2-mercaptothiazoline and chloroethylamine in an acidic solvent, such as hydrochloric acid or acetic acid, in >=5wt.% concentration at 70 deg.C - refluxing temperature for 5-30hr to vacuum concentrate the resultant reaction solution and separate the aimed compound, such as 4- methyl-5-[(2-aminoethyl)-thiomethyl]-imidazole hydrochloride, expressed by formula III and useful as a synthetic intermediate for cimetidine which is an antiulcer agent having inhibitory action on histamine H2 receptor, etc., as a solid substance. The resultant substance is then recrystallized from a alcohols to afford the aimed compound. |
| priorityDate | 1987-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.