http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6452741-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e43b4ca6b41ce9f54c9a895d474c81a |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B57-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1987-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e9583f526eaaf4c2305f929daa4f5f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81f6f771b1b0b02fffcf2a76a574f1eb |
| publicationDate | 1989-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6452741-A |
| titleOfInvention | Novel process for producing optically active 1-(p-tolyl) ethylamine |
| abstract | PURPOSE:To obtain the titled compound useful as an optical resolution agent, in high yield and purity, by reacting (+ or -)-1-(p-tolyl)-ethylamine with an inexpensive resolution agent and separating the produced diastereomer salt taking advantage of the solubility difference. CONSTITUTION:(+ or -)-1-(p-Tolyl)ethylamine is made to react with 0.6-1.2 equivalent of a resolution agent comprising optically active 2-pyrrolidone-5-carboxylic acid or optically active 2-(6-methoxy-2-naphthyl)propionic acid in a solvent (e.g. 2-propanol) preferably at a temperature between about 50 deg.C and the boiling point of the solvent. The reaction product is heated and dissolved to form a supersaturated solution. If necessary, the solution is added with a small amount of a diastereomer salt having lower solubility in said solvent among the two kinds of the diastereomer salts and cooled preferably to 0-50 deg.C. The precipitated hardly soluble salt is separated to obtain the objective compound. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658784-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108658784-A |
| priorityDate | 1987-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.