http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6442418-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f84747e8d08b1023763356d0e7d1db68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18698187940245cef82d2e72c284d50f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 |
| filingDate | 1987-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0718435bd9f594321a53403feafce37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c38a70569b2fe1582a99b40ede3c1769 |
| publicationDate | 1989-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6442418-A |
| titleOfInvention | Liposome/anthraquinone drug composition and therapy therewith |
| abstract | PURPOSE: To obtain a medical composition reduced in peroxylipids and free radial injuries by introducing a lipophilic free radical scavenger into a lipid bilayer part of a liposome and including a trihydroxamic chelating agent in the composition. CONSTITUTION: This composition comprises a liposome containing at least 0.1mol%, preferably 0.2-2mol% lipophilic free radical scavenger (e.g. α-tocopherol) introduced into a lipid bilayer part, an anthraquinone medicine having a quinone and a hydroquinone functional part in the adjacent anthraquinone ring (e.g. an anthracycline glycoside-based antibiotic agent such as doxorubicin or daunorubicin) and a trihydroxamic acid chelating agent present as a ferric ion in an excessive molar amount such as ferrioxamine. The size is mainly within the range of 0.05-0.25μm. An aqueous suspension containing at least 2.5mol% doxorubicin or its analog is administered to treat primary or secondary tumor of the liver. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2003512313-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2005513104-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5583058-A |
| priorityDate | 1985-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.