| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1374dd16777534b65ad4422333245af8 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-19 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
1987-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad260c19afd2a4635c0ade016fa1281f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f64e3fdfb5652ebcbb5329be5ed7ae9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50bf2573d87ec93fd2060f88ec3b2b30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1140fe5228c2fe6e74684110a15da115 |
| publicationDate |
1989-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S6437299-A |
| titleOfInvention |
Novel physiologically active polypeptide |
| abstract |
NEW MATERIAL:The polypeptide having an amino acid sequence of formula. USE:An antitumor agent. PREPARATION:For example, gene of human tumor necrosis factor (TNF) is chemically synthesized by selecting the amino acids constituting human TNF protein from a designated codon. The gene is linked with a proper vector and closed to obtain an expression-type plasmid. The plasmid is cut with a proper restriction enzyme to remove a specific region in the human TNF gene and the gene is repaired by using an oligonucleotide having another base sequence to obtain a recombinant plasmid containing a DNA region coding a polypeptide having methionine group bonded to an amino terminal. The plasmid is inserted into a microorganism and the transformed microorganism is cultured to obtain the polypeptide having the amino acid sequence of formula. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9117180-A1 |
| priorityDate |
1987-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |