http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S643563-A

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filingDate 1987-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b8fccba3af19027e834a404e0f71a2fb
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publicationDate 1989-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S643563-A
titleOfInvention Reagent for immunoassay
abstract PURPOSE:To improve measurement sensitivity by housing a soln. of nitro PAPS into an endoplasmic reticulum having a membrane labeled by an antigen or antibody. CONSTITUTION:This reagent has preferably the endoplasmic reticulum which has the membrane labeled with the antigen or antibody and is housed internally with the soln. of the nitro PAPS and a liquid in which this endoplasmic reticulum is dispersed and contains the metal ions capable of forming a colorable complex between the same and the nitro PAPS. The metal ions include Ni(II), Co(III), Fe(II), Zn(II), Cu(II), etc. The nitro PAPS has high water solubility, can be dissolved at several hundreds millimol or above in 1l buffer soln. and is capable of increasing the concn. of the chelate agent housed in the endoplasmic reticulum. The complex forming reaction between the nitro PAPS and the metal ions is sensitive and the coefft. of molecular absorption is as high as order of 10<5>. Since the absorption wavelength of this complex exists mostly at >=600nm, the errors by the absorption of extraneous matter are decreased. The measurement sensitivity is thus improved.
priorityDate 1987-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 26.