http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S6391097-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6cfc033f059d282fcd915bc8be2ae53f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-00 |
| filingDate | 1986-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32097d7eeefdebb5e41e989996d630c2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b7aa71ba5053fffbba01e1c7c99f084 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df18d82388a6ec7d8be05db2941d420a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_835077a12a6c5af9b3c496b2d711edb4 |
| publicationDate | 1988-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S6391097-A |
| titleOfInvention | Separation of d-phenylalanine |
| abstract | PURPOSE: To obtain D-phenylalanine useful to analgesic, etc., and having high optical purity, by optically resolving N-acetyl-DL-phenylalanine, again optically resolving a filtrate separated from L-phenyl alanine crystals, dissolving the L-phenyl alanine and hydrolyzing a solid separated after the dissolution. n CONSTITUTION: 5W40% aqueous solution of N-acetyl-DL-phenylalanine is made to neutral W weakly alkaline solution with NaOH, etc., and as necessary CoCl 2 is added to the solution to provide 10 -6 W10 -2 M Co ion concentration and the solution is subjected to hydrolysis reaction at 30W60°C for 10W70hr using an acylase enzyme to optically resolve the phenylalanine. The resultant acylase hydrolysate is concentrated and cooled and deposited L-phenylalanine crystals are separated by filtration and removed. Then the filtrate consisting of N-acetyl- D-phenylalanine and unreacted N-acetyl-L-phenylalanine is again optically resolved and pH thereof is made to ≤1 to dissolve the remaining L-phenylalanine produced and deposited N-acetyl-D-phenylalanine containing no unreacted raw material. The resultant N-acetyl-D-phenylalanine is subjected to solid-liquid separation, hydrolyzed, cooled, neutralized and deposited crystals are separated. n COPYRIGHT: (C)1988,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4912042-A |
| priorityDate | 1986-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.