| abstract |
NEW MATERIAL:A compound of formula I (R is H or residue of monohydric alcohol; the bond containing dotted line is double bond or triple bond). n EXAMPLE: 20,20,20-Trifluoroarachidonic acid. n USE: An agent for controlling arachidonic acid metabolism. It is effective in preventing the deactivation of the acid by ω-oxidation in living body. n PREPARATION: The compound of formula I can be produced by a conventional process comprising a reaction of a fluoroaldehyde of formula II with a Witting reagent having the hydrocarbon chain of formula III and treated with a strong base. The Witting reagent of formula III is preferably the compound of formula IV (R 1 is alkyl, aryl or aralkl; X is halogen). n COPYRIGHT: (C)1988,JPO&Japio |