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filingDate 1987-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf25b94536056607a8c2e5acc6476b8a
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publicationDate 1988-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-S6360996-A
titleOfInvention 4-or 6-substituted aldosteronic acid, production and use thereof in immunoassay
abstract NEW MATERIAL:A compound expressed by formula I [when R 1 is H, R 2 represents -S-(CH 2 ) 1W3 COR 3 or -O-CO-(CH 2 ) 1W3 COR 3 , and when R 2 is H, R 1 represents -S-(CH 2 ) 1W3 COR 3 ; R 3 represents OH or optionally iodinated tyramine residue, tyrosine lower alkyl ester residue, histamine residue, histidine residue or 7-aminoheptanoyltyrosine lower alkyl ester residue]. n EXAMPLE: (11β, 18-Epoxy-18α,21-dihydroxy-3,20-dihydroxy-3,20-dioxo-4-pregnen-4- ylthio)acetic acid. n USE: A hapten for measuring serum aldosterone, having all functional groups thereof in a free state, usable as the hapten for producing an anti-hapten antiserum, and capable of being labeled with radioactive iodine, enzyme, etc. n PREPARATION: A compound expressed by formula II (X represents glycol- protecting group) is subjected to deprotection reaction preferably at room temperature in a stream of an inert gas under acidic condition. n COPYRIGHT: (C)1988,JPO&Japio
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015046444-A1
priorityDate 1987-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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