| abstract |
PURPOSE: To obtain the titled inhibitor containing a Bowman-Birk type trypsin inhibitor derived from soybean as an active ingredient. n CONSTITUTION: A degranulation inhibitor for mast cells obtained by containing a Bowman-Birk type trypsin inhibitor derived from soybean (BBI; 6,000W8,000 mol.wt., present in water-soluble fraction of soybean together with a Kunitz type trypsin inhibitor having about 20,000mol.wt.) as an active ingredient. The natural BBI is obtained by concentration and fractionation using extraction with an aqueous medium or polar organic solvent, e.g. lower alcohol, lower aliphatic ketone, etc., separation with a membrane, isoelectic precipitation, etc., to give a crude purified substance, subjecting the resultant substance to purifying means, e.g. gel filtration, etc. Since the BBI is capable of acting on mast cells and inhibiting the degranulation thereof, it may be effective against allergic diseases. n COPYRIGHT: (C)1988,JPO&Japio |