| abstract |
NEW MATERIAL:The compound of formula I [R 1 and R 2 are H, halogen, NO 2 , alkyl, amino, OH, alkoxycarbonyl or together form (CH 2 ) m (m is 3W5) or O-(CH 2 ) n -O (n is 1W3); R 3 is H or alkyl; R 4 and R 5 are H, halogen, alkyl or OH; A is alkylene] or its acid addition salt. n EXAMPLE: 2-{3-[4-(4-Fluorophenyl)-1-piperazinyl]-propyl}-6, 7, 8, 9-tetrahydro-2H- naphtho[2,3-b][1,4]-oxazin-3(4H)-one. n USE: A drug having strong hypotensive and vasodilating action, etc. n PREPARATION: The compound of formula I can be produced e.g. by reacting the compound of formula II (X is eliminable group) with the compound of formula III in the presence of a proper acid acceptor 50W150°C. n COPYRIGHT: (C)1988,JPO&Japio |