| abstract |
NEW MATERIAL:A compound expressed by the formula having following physicochemical properties; Elementary analysis (%): C 59.55, H 8.32, N 15.90; Molecular weight: 502.65; Molecular formula: C26H42O4N6; Melting point: 163-166 deg.C (decomposition); [alpha]<22>D = -30.5 + or - 1.5 deg. (c=1.105, CH3OH); Soluble in methanol, ethanol and dimethyl sulfoxide, and hardly soluble in water, acetone, ethyl acetate, ether, chloroform and petrolum ether; Positive to the Sakaguchi reaction, Rydon-Smith reaction and 2,3,5-triphenyltetrazolium chloride and negative to ninhydrin reaction, etc. USE:A protease activity inhibitor. PREPARATION:A bacterial strain belonging to Genus of Streptomyces such as Streptomyces.Sp-AK-33 strain (FERM P-885), etc. is cultured, preferably under an aerobic condition at 28 deg.C for 2-4 days. |