| abstract |
NEW MATERIAL:The compound of formula I (R 1 is lower alkyl; R 2 and R 3 are alkyl or together form a cyclic amino with bonded N and in some case with O, S, SO or SO 2 ; A is nitrile or lower alkoxycarbonyl). n EXAMPLE: 3-Dimethylamino-2-(3-methoxy-2,4,5-trifluorobenzoyl)acrylic acid methyl ester. n USE: A synthetic intermediate for 8-alkoxyquinolonecarboxylic acid derivative useful as an antibacterial agent. n PREPARATION: The compound of formula I can be produced by reacting a substituted benzoyl halide compound of formula II (X is halogen) with a 3- aminoacrylic acid derivative of formula III in a solvent (e.g. THF) in the presence of a base (e.g. triethylamine) at -30W170°C. n COPYRIGHT: (C)1988,JPO&Japio |