| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 is H, 2-propenyl, 1W4C alkyl; R 2 is H or 1W3C alkyl; X is Cl or Br; Y is H, nitro or NHR 3 (R 3 is H or 1W4C alkyl), or AR 4 (A is O or S; R 4 is 1W6C alkyl, 3W6C alkenyl, etc.; Z 1 is H or 1W4C alkyl, OR 6 (R 6 is H or 1W8C alkyl), halogen, etc.; Z 2 is Z 1 excluding H, etc.]. n EXAMPLE: 4-Chloro-5-( 3-n-butoxy-4-methoxybenzylamino )-6-ethoxy-3-(2H)pyrida zinone. n USE: A medicine. SRS-A antagonist. An active ingredient of medicine for preventing or treating disease caused by either one of leukotrikon C 4 , D 4 and E 4 or mixture thereof. n PREPARATION: A compound expressed by formula II (Ya is H, nitro, amino, OR 4 or halogen) is reacted with a compound expressed by formula III in a solvent, as necessary in the presence of a deacidificating agent to provide the compound expressed by formula I wherein Y is Ya. n COPYRIGHT: (C)1988,JPO&Japio |