| abstract |
NEW MATERIAL:A compound shown by formula I [ring Het is pyrrolyl, furyl or thienyl; X is single bond or lower alkylene; A is alkylene; R 1 WR 3 are H, halogen or lower alkyl; R 4 is H, lower alkyl or hydroxy; R 5 and R 6 are group shown by formula II (R 9 is H or lower alkyl; R 10 is phenyl or R-containing heteroaryl; q is 2 or 3)]. n EXAMPLE: N-[4-(4-Diphenylmethylene-1-piperidinyl)butyl]-4-hydroxy--7-methyl-1,8- naphthyridine-3-carboxamide. n USE: An antiallergic agent having inhibitory action on 5-lipoxygenase. n PREPARATION: A compound shown by formula III or a reactive derivative thereof is reacted with a diamine shown by formula IV in the absence of a solvent or in a solvent such as chloroform optionally in the presence of a base (e.g. triethylamine) at -40W200°C to give a compound shown by formula I. n COPYRIGHT: (C)1988,JPO&Japio |