| abstract |
PURPOSE: To provide the titled composition composed of a physiologically active polypeptide, a specific natural bile acid and a water-absorbing solid base and effective in efficiently absorbing the polypeptide through nasal mucosa. n CONSTITUTION: The objective composition contains (I) a physiologically active polypeptide (e.g. calcitonin), (II) a natural bile acid of formula (D is OH, -NHCH 2 COOH, etc.; V is H or β-OH; W is H, α-or β-OH; X, Y and Z are H, α-or β-OH or =O; when all X, Y and Z are OH and both V and W are H, then D is OH or -NHCH 2 CH 2 SO 3 H) and/or its salt as an absorbefacient and (III) a water-absorbing solid base suitable for the application to nasal mucosa. Preferably, ≥90wt% of the particles of the composition has an effective diameter of 10W250μ to enable uniform distribution over nasal mucosa and stable retention to the attached part when administered to nasal cavity and to enable the administration to nasal cavity in high efficiency when sprayed into nasal cavity through nare in the form of powdery drug. n COPYRIGHT: (C)1988,JPO&Japio |