| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 and R 4 are amino or organic group linked through N; R 2 is H or (substituted)alkyl; R 3 is H or protecting group; R 5 is (substituted)OH or (substituted)amino; provide that when R 1 is amino, sorbilamino or hexanoylamino and R 2 is H or methyl and R 4 is amino which may be protected and R 5 is OH or 2-amidinoethylamino, R 3 is protecting group] or salt thereof. n USE: A remedy for bacterial infectious disease or antimicrobial agent. n PREPARATION: For example, a compound expressed by formula IV obtained by using a compound expressed by formula IX wherein each functional group other than carboxyl group in α-position is properly protected led from d-, l- or dl- amino acid as a starting material is subjected to reduction reaction in the presence of a compound expressed by the formula H 2 NA [A is H, (substituted)alkyl, etc.] or salt thereof to provide the aimed compound expressed by formula I. n COPYRIGHT: (C)1988,JPO&Japio |