http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S63267797-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6384fc75126d4a03b18a5f16b33ca244 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate | 1987-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6508b9319077228d4b90da048424cb2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b43c82104c6c6c6e0e1f746b47b5c404 |
| publicationDate | 1988-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S63267797-A |
| titleOfInvention | Novel betamethasone derivative, its production and enzyme immunoassay using the same |
| abstract | NEW MATERIAL:{[11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methyl-3,20-dioxopre gna-1,4-diene-4-yl]thio}acetic acid. n USE: Hapten for making antibodies, labeled antigen. n PREPARATION: The dihydroxyacetone side chain in the 17 position of betamethasone of formula II is protected in the form of bismethylene dioxide, the product is brominated to give (6β,11β,16β)-6-bromo-9-fluoro-11-hydroxy-16- methyl-17,20,20,21-bis[methylenebis(oxy)pregna-1,4-diene-3-one of formula III. The product is allowed to react with thioglycolic acid to form {[(11β,16β)-9- fluoro-11-hydroxy-16-methyl-17,20,20,21-bis[ methylenebis(oxy)) ]-3-oxopregna-1,4- diene-4-yl]thio}acetic acid. Then, the protecting group in the 17 position is removed. n COPYRIGHT: (C)1988,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103940999-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112341510-A |
| priorityDate | 1987-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.