| abstract |
NEW MATERIAL:A compound of formula I (R<1> is H, lower alkyl, halogenated (lower)alkyl, aryl; R<2> is H, hydroxyl; R<3> is H; R<4> is lower alkyl, amino-(lower) alkyl, carboxy-(lower)alkyl; R<5> is H, lower alkyl; R<2> and R<3> may incorporate to form oxo group). EXAMPLE:0-[2-Diazo-3(R)-hydroxyl-1-oxobutyl]-L-serine. USE:Antitumor agent. PREPARATION:The reaction of a compound of formula II with an alkali metal nitrite such as potassium nitrite is carried out in a usual solvent under cooling to under heating to give the compound of formula I. |