| abstract |
NEW MATERIAL:A compound shown by formula I [R 1 is cyclopropyl which may contain 1W3 substituent groups (alkyl or halogen); R 2 is 5W9-membered (substituted)heterocyclic residue; R 3 is alkyl which may contain 1W3 substituent groups (5W6-membered heterocyclic residue, alkylthio, amino OH or alkoxy); X is halogen] or a salt thereof. n EXAMPLE: 7-(1-Piperazinyl)1-cyclopropyl-6-fluoro-8-methyl-1,4-dihydro-4-oxoquino line-3-carboxylic acid. n USE: An antibacterial agent having excellent antibacterial activity widely against Gram-positive and Gram-negative bacteria. n PREPARATION: A compound shown by formula III (R 5 is alkyl) obtained by using a compound shown by formula II (R 2 ' is halogen or R 2 ; X 2 is halogen) as a raw material is subjected to ring formation to give a compound shown by formula IV, which is hydrolyzed to give a compound shown by formula I. n COPYRIGHT: (C)1988,JPO&Japio |