| abstract |
PURPOSE: To obtain phenylalaninol in one-stage reaction, by catalytically reducing propanediol with sulfuric acid in the presence of a palladium catalyst, dehydroxylating the resultant product and treating the resultant compound. n CONSTITUTION: 3-Phenyl-2-amino-1,3-propanediol expressed by formula I or an optically active substance thereof is catalytically reduced with sulfuric acid. The above-mentioned reaction is carried out in an alcoholic or water solvent in the presence of a palladium catalyst, such as palladium carbon, at 30W100°C under ordinary pressure for 6W12hr. The reaction product is then treated with an alkali (e.g. NaOH) to provide pH≥11 and afford the aimed substance expressed by formula II. The molar amount of the sulfuric acid used for the reduction is once or more, preferably ≥3 times based on the compound expressed by formula I. n COPYRIGHT: (C)1988,JPO&Japio |