| abstract |
NEW MATERIAL:The compound of formula I [Ar is phenyl having nitro, cyano, etc., as substituent or group of formula II; Ph and Ph' are (substituted)phenyl; R 1 is H or lower alkyl; R 2 is (substituted)alkyl, cycloalkyl, cycloalkyl-lower alkyl, lower alkenyl or cinnamyl; n is 1W3] and its acid addition salt. n EXAMPLE: 2-Amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzhydryl-3-acetidienyl) ester 5-isopropyl ester. n USE: A calcium antagonistic agent, a hypotensor, a vasodilator, an agent for ameliorating hyperlipemia and an agent for inhibiting formation of lipid peroxide. n PREPARATION: A 2-benzylidene acetoacetic acid ester derivative of formula IV is made to react with an amidinoacetic acid ester of formula V. n COPYRIGHT: (C)1988,JPO&Japio |