| abstract |
NEW MATERIAL:The compound of formula I (M is 5W7-membered heterocyclic base containing two N atoms.; A is substituent group on one of the N atoms. of the group M and is H, aryl, aralkyl, heteroaryl, heteroaralkyl or cycloalkyl; M is a group bonded to the other N atom. of the group M and is single bond or lower alkylene; B is group of formula II; R 1 is amino, hydrazino, guanidino, isothioureido or thioureido) and its salt. n EXAMPLE: 1-( 4-Fluorophenyl )-4-( 2-guanidino-1,3-thiazol-4-yl )methylpiperazinehy drochloride. n USE: It has excellent Gasping prolonging action and antagonistic action against lethal hypoxia. It is non-toxic and is useful as a cerebral function improver. n PREPARATION: The compound of formula can be produced e.g. by reacting an amino compound of formula A-M-H with a compound of formula III (X is halogen, alkanesulfonyloxy, etc.). n COPYRIGHT: (C)1988,JPO&Japio |