| abstract |
NEW MATERIAL:A compound expressed by formula I (R is nitrogen-containing heterocyclic monocyclic group which may have a substituent group; ring A is phenyl which may have a substituent group; Y is vinylene or ethylene; m is 1W6; n is 0, 1 or 2; Q is methylene or single bond) or salt thereof. n EXAMPLE: (E)-1-Cinnamyl-3-(3-pyridyl)-2-imidazolidinone. n USE: A medicine, having excellent cerebral metabolic activating action, antidementia action and antidepressant action, etc., and useful as a cerebral activator and further inhibitory action on gastric acid secretion and also for treating preventing peptic ulcer. n PREPARATION: (A) A compound expressed by formula II (X 1 is reactive residue) and a compound expressed by formula III or salt thereof are subjected to condensation reaction or (B) a compound expressed by formula IV is or salt thereof is reacted with a carbonylating agent. Alternatively, (C) a compound expressed by formula V or salt thereof is reacted with an oxidizing agent, etc., to afford the aimed compound expressed by formula I. n COPYRIGHT: (C)1988,JPO&Japio |