| abstract |
NEW MATERIAL:A compound shown by formula I [A is H 2 H- or group shown by formula II; B is group shown by formula II or -C(CH 2 ) 2 - (n is 3W5); X is H, hydroxyl or nitro; Y is group shown by formula IV (R 1 and R 2 are H, phenyl or 1W4C alkyl)]. n EXAMPLE: N-(5-Aminovaleryl)-L-phenylalanine 4-benzoylanilide. n USE: A protease inhibitor having extremely strong inhibitory activity against plasmin, kallikrein, trypsin and urokinase. n PREPARATION: A compound shown by formula V (Boc is t-butyloxycarbonyl) as a starting substance is successively reacted to give a compound shown by formula VI, which is then deprotected by the use of dioxane to give a compound shown by formula I. n COPYRIGHT: (C)1988,JPO&Japio |