| abstract |
NEW MATERIAL:Optically active (l or d) 2-methyl-1-(4-trifluoromethylphenyl)-3- pyrrolidino-1-propan-one. n USE: A medicine. A central muscle relaxant. The compound is expected to have excellent remedying effect in ameliorating spastic paralysis caused by cerebrovascular diseases, cerebral palsy, spondylopathy, etc., or hypermyotonia in various diseases. It can be administered orally or parenterally at a dose of usually 0.1W20mg/kg body weight/day. n PREPARATION: DL.2-methyl-1-( 4-trifluoromethylphenyl )-3-pyrrolidino-1-propano ne is reacted with an optically active acetylphenylglycine in a solvent (e.g. isopropanol) to form two kinds of corresponding diastereomer salts. The salts are subjected to optical resolution in an alkyl acetate and the crystallized diastereomer salt is decomposed to separate the above novel substance. n COPYRIGHT: (C)1988,JPO&Japio |