| abstract |
PURPOSE: To obtain a composition for exodermal administration containing indomethacin or diazepam and 1-nonene, p-menthane, etc., and a specific dissolvent and having enhanced percutaneous absorbability of the above-mentioned drug. n CONSTITUTION: A composition obtained by containing (A) indomethacin or diazepam, (B) a compound selected from 1-nonene, p-menthane, α-terpinene, n-butyl- or tert-butylcyclohexane, dipentene, pinane, ethylcyclohexane, biphenyl, n-butylbenzene, myrcene, methylcyclopentadiene dimer, cis-1,3-dimethylcyclo hexane, dicyclohexyl, dimethylnaphthalene, etc., (C) a dissolvent selected from a lower alcohol, glycols and pyrrolidones at 5:95W75:25, preferably 10:90W30:70 weight ratio of the ingredients (B):(C). The amount of the ingredient (A) is 0.01W20wt.%, preferably 0.2W10wt.% based on the total amount of the ingredients (B) and (C). n COPYRIGHT: (C)1988,JPO&Japio |