| abstract |
NEW MATERIAL:1,2-Dihydronaphthalene derivatives expressed by formula I [R 1 and R 2 are H, alkyl, halo lower alkyl, -(CH 2 ) m O 2 R 3 , -(CH 2 ) m CONR 3 R 4 (R 3 and R 4 are H or alkyl; m is 0 or 1), -(CH 2 ) n NR 3 R 4 (n is 1 or 2) or -(CH 2 ) n OR 3 (the wedge line and the broken lines indicate that the substitutent groups at the 1- and 2-positions are mutually in the trans-configuration; R 1 and R 2 are not methyl at the same time)] and salts thereof. n EXAMPLE: 2,3-Diethyl-1,2-dihydro-5,7,8-trimethoxy-1-(2,4,5-trimet-hoxyphenyl)naph thalene. n USE: An immunological enhancer having effects similar to those of well-known magnoshinin (R 1 and R 2 are methyl). n PREPARATION: For example, a compound expressed by formula II (R 1 ' and R 2 ' have the same meaning as that of R 1 and R 2 ) is treated with an acid to afford the aimed compound expressed by formula III which is one of the compounds expressed by formula I. n COPYRIGHT: (C)1988,JPO&Japio |