| abstract |
NEW MATERIAL:A derivative expressed by formula I (R 1 is H, halogen or lower alkyl; R 2 is H or lower alkoxy) or acid addition salt thereof. n EXAMPLE: O-Benzylsalicyl 4-guanidinomethylbenoate. n USE: A remedy for peptic ulcer useful as a medicine having high remedial effects with hardly any side effects. n PREPARATION: A 4-guanidinomethylbenzoic acid expressed by formula II is reacted with phenols expressed by formula III in the presence of a condensing agent, such as dicyclohexylcarbodiimide, to afford the aimed compound expressed by formula I. The reaction is preferably carried out in a solvent, such as DMF, pyridine or toluene, at room temperature W 140°C for 30minW24 hr. The compound expressed by formula II is obtained by amidinating p- aminomethylbenzoic acid with S-methylisothiourea. n COPYRIGHT: (C)1988,JPO&Japio |