http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S63216887-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9822bceff022feda91b10019125e70f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-00 |
| filingDate | 1987-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b466a633772259ebd6ee737b1d55300 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1437f4405d66d7548bdb74495c5fd6a5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_202d48f90d70811a7f24b245aac00325 |
| publicationDate | 1988-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S63216887-A |
| titleOfInvention | 5-oxa-1,3,4,5-tetrahydrobenz(cd)indole derivative |
| abstract | NEW MATERIAL:The compound of formula I (R<1> is H or arenesulfonyl; R<2> i s cyano or carboxyl; R<3> is H or lower alkyl). USE:A carcinostatic agent. PREPARATION:The compound of formula I can be produced e.g. by reacting 4-hydroxyindole of formula II with bromoacetonitrile, acetylating 3-site and tosylating 1-site of the product, reacting the resultant compound with p- toluenesulfonylhydrazine, suspending the obtained compound of formula III (Ts is tosyl) e.g. in diglyme, adding oil-based sodium hydride to the suspension, heating and refluxing the mixture in argon stream to effect cyclization reaction and removing 1-tosyl group from the product. |
| priorityDate | 1987-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.