| abstract |
NEW MATERIAL:A compound expressed by formula I (R 1 is amino or OH; R 2 is H or lower alkyl; R 3 is lower alkyl; R 4 is H or phosphoric acid residue) or salt thereof. n EXAMPLE: 2'-Deoxy-2'(S)-methylcytidine. n USE: An antiviral agent. n PREPARATION: A saccharide part at the 2'-position of a compound expressed by formula II (R 5 is alkoxyl; Z is protecting group) is alkylated with an alkylating agent to provide a compound expressed by formula III. The OH group at the 2'-position of the compound expressed by formula III is then acylated, reduced with a reducing agent and deprotected to afford a compound expressed by formula IV. The base part at the 4-position of the compound expressed by formula IV is subsequently hydrolyzed or aminated and, as desired, the saccharide part at the 5'-position is then phosphorylated. n COPYRIGHT: (C)1988,JPO&Japio |