| abstract |
NEW MATERIAL:An isoquinolinesulfonamide derivative shown by formula I [R is amino lower alkylamino, mono- or di- (lower alkyl) amino lower alkylamino or homopiperazinyl] and an acid addition salt thereof. n EXAMPLE: 1-(1-Hydroxyisoquinoline-4-sulfonyl)homopiperazine hydrobromide. n USE: Having inhibitory action on calmodulin and on activity of myosin light chain kinase following calmodulin, relaxing action on smooth muscle and vasodilating action, useful as a vasodilator, hypotensor, cerebral circulation improver, remedy for angina pectoris, preventive and remedy for thrombosis of brain-heart blood vessel system. Being administered by injection, orally or through mucosa. n PREPARATION: A sulfonic acid halogenide derivative shown by formula II (X is halogen) is treated with an amine derivative shown by formula III to give a compound shown by formula I. n COPYRIGHT: (C)1988,JPO&Japio |