| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6e960aa6ad2ba6401030159343ebe68 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-44 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C313-00 |
| filingDate |
1987-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d0fc254934aaaaa71a763570409fd28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_686c00fa0664990963c33689b0227ee3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a274c942c58cf53a52acbe10ddc196be
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c3ef64fda50cf25e9e10ab732da9dbf |
| publicationDate |
1988-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S63201164-A |
| titleOfInvention |
Cyanoguanidine derivative and production thereof |
| abstract |
NEW MATERIAL:A compound shown by formula I (R is lower alkyl; R' is H or lower alkyl). n EXAMPLE: N-Cyano-N'-[2-(3-formamino-2-oxobutylthio)ethyl]-N"-methylguanidine. n USE: A synthetic intermediate for cimetidine, a remedy for gastric ulcer, showing inhibitory action on secretion of acid in the stomach based on histamine H 2 - acceptor antagonism. Cimetidine is obtained in a readily treatable way at a few reaction stages in high yield. n PREPARATION: A haloketone derivative shown by formula II (X is Cl or Br) is reacted with an ammonium salt and a lower fatty acid salt (e.g. ammonium formate) in a double layer solvent of formamide and chloroform at 0W100°C to give a compound shown by formula I. n COPYRIGHT: (C)1988,JPO&Japio |
| priorityDate |
1987-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |