| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 represents H or acetyl; R 2 represents H or OH; A represents N(R 3 )R 4 [R 3 represents 1W5C alkyl, etc.; R 4 represents 1W5C alkyl, -(CH 2 ) a X 1 (a is 1W4; X 1 represents ethynyl, cyano, etc.), etc.], formula II (formula III represents 2W9C and 3-W10-membered cyclic amino; X 2 represents H or 1W4C alkyl; X 3 represents H, 1W3C alkyl, OH, etc.), etc.} and salts thereof. n USE: An antibacterial agent against Gram-negative bacteria and acid-fast bacteria used by oral administration with low toxicity. n PREPARATION: A rifamycin derivative expressed by formula IV is reacted with an amine expressed by the formula AH. n COPYRIGHT: (C)1988,JPO&Japio |