| abstract |
NEW MATERIAL:The 2-quinolylmethyl=sulfide derivative of formula I [R 1 is group of formula IIWIV (R 2 is H or lower alkyl; R 3 and R 4 are saturated or unsaturated lower alkyl, NH 2 or aryl)]. n EXAMPLE: 1-Methyl-2-(2-quinolylmethyl)isothiourea. n USE: Pharmaceuticals having strong positive inotropic action to cardiac muscle, platelet coagulation action, antiedemic action, H 2 -receptor inhibiting action, etc. n PREPARATION: The compound of formula I can be produced from an inexpensive raw material with simple operation by reacting 2-chloromethylquinoline with a compound of formula V W formula VI (R 4 is -NHCH 2 CH 2 - or -SC(NH 2 )= N-) in one or more polar solvents preferably selected from methanol, ethanol and acetone preferably at room temperature or under heating (at room temperature in the case of the compound of formula VI) under stirring. n COPYRIGHT: (C)1988,JPO&Japio |