| abstract |
NEW MATERIAL:A compound expressed by formula I [R 1 is (protected) carboxy; R 2 is (protected) hydroxy (lower) alkyl; R 3 is H or lower alkyl; R 4 is (protected) ureido (lower) alkyl; R 5 is H, lower alkanimidoyl or imide-protecting group; A is lower alkylene] and salts thereof. n EXAMPLE: (4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(2S,4S)-2-{(2-ureidoethyl)oxymethyl}pyrrolidin-4-yl]thio-1-azabicyclo[3.2.0]hept-2-ene-2-carbo xylic acid. n USE: An antimicrobial agent, extremely stable to dehydropeptidase and capable of exhibiting high discharge into urine. n PREPARATION: For example, a compound expressed by formula II is reacted with a compound expressed by formula III to afford the aimed compound expressed by formula I. n COPYRIGHT: (C)1988,JPO&Japio |