| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd727aa2b4e6c347aadd94971881d671 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-782 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-602 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7028
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7034
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-60 |
| filingDate |
1987-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_277867bfec848b4fb8b94b9a398edd62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f08b410a469fa57ef941ed27d6b4640
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c29de69bdcdb1d7d23188d9ff358508e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5dade147e42f78fd4b9a6665efc51fcf |
| publicationDate |
1988-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-S63174910-A |
| titleOfInvention |
External drug for skin |
| abstract |
PURPOSE:To obtain an external drug having suppressed browning tendency of arbutin with time, by using arbutin having skin-beautifying effect in combination with sodium bisulfite. CONSTITUTION:The objective external drug for skin contains arbutin (hydroquinone-beta-D-glucopyranoside) and sodium bisulfite at a weight ratio of 1:0.0001-1 (preferably 1:0.001-0.1). The amount of arbutin in the whole drug is 1-20wt.%. Arbutin is active to inhibit tyrosinase which is an enzyme participating in the formation of melanin pigment and exhibits skin-beautifying effect, however, it has a tendency to discolor from pale yellow to brown with time under exposure to sun light or by the storage at a high temperature. The defect can be eliminated by using sodium bisulfite especially at pH 4-7. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6497860-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012126684-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9633722-A1 |
| priorityDate |
1987-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |