| abstract |
NEW MATERIAL:The compound of formula I (R 1 is H, halogen, lower alkoxy, OH, etc.; R 2 is H or lower alkyl; R 3 is H, carbamoyl, carboxy, etc.; Y is O, S or imino; X is phenylene, propenylene, etc.; n is 1W5; group of formula IV is 4W6-membered heterocyclic group which may be condensed with a benzene ring) and its acid addition salt. n EXAMPLE: m-(Piperidinomethyl)phenyl N-(m-chlorophenyl)carbamate. n USE: Useful as a remedy for diseases of central nervous system, especially diseases caused by neural degeneration (e.g. Alzheimer's disease, Huntington's chorea, etc.). n PREPARATION: The compound of formula I can be produced by reacting an amine of formula III with a compound of formula II (A is halogen or organic sulfonic acid residue) having halogen atom or an organic sulfonic acid residue at an alkyl group terminal. n COPYRIGHT: (C)1988,JPO&Japio |