| abstract |
NEW MATERIAL:A compound expressed by formula I {R 1 WR 3 are H, halogen trifluoromethyl, lower alkyl, lower cycloalkyl, nitro, amino, (substituted)phenyl, etc.; R 4 is H, lower alkyl or (di)aralkyl, R 6 -CO- [R 6 is lower alkyl, lower cycloalkyl, (substituted)phenyl, etc.], etc.} or acid addition salt thereof. n EXAMPLE: 9-Amino-1,2,3,4-tetrahydro-1,4-ethano-1-azaacridine. n USE: Useful as a remedy for senile dementia having excellent inhibitory action on acetylcholine esterase. n PREPARATION: A 2-aminobenzonitrile derivative expressed by formula II, e.g. 2-amino-6-fluorobenzonitrile, etc., is reacted with a 3-quinuclidine expressed by formula III to afford the aimed compound expressed by formula I (group R 4 is H). n COPYRIGHT: (C)1988,JPO&Japio |